A Convenient Synthesis of p-Aminobenzyl-tris(hydroxymethyl)methane as Precursor of Solid-Supported Tripodal Ligands

Eric Dulière; Jacqueline Marchand-Brynaert

doi:10.1055/s-2002-19291

PAPER

A Convenient Synthesis of p-Aminobenzyl-tris(hydroxymethyl)methane as Precursor of Solid-Supported Tripodal Ligands

Eric Dulière, Jacqueline Marchand-Brynaert*
Unité de chimie organique et médicinale, Université catholique de Louvain, Département de chimie, Bâtiment Lavoisier, place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium
Fax: +32(10)474168; e-Mail: marchand@chim.ucl.ac.be;

Abstract

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Abstract

p-Aminobenzyl-tris(hydroxymethyl)methane has been prepared in 5 steps from diethylmalonate and p-nitrobenzyl bromide, with an overall yield of 23%. This compound could be grafted on silica previously derivatized with 3-isocynatopropyltriethoxysilane.

Key words

tris(hydroxymethyl)methane derivatives - tripodal ligands - amino alcohols - solid-phase synthesis

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References

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